Simple Test May Predict If a Coma Patient Will Wake

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Optical illusions may seem like nothing more than visual trickery.


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Optical Illusions: Your Brain Is Way Ahead of You

Optical illusions may seem like nothing more than visual trickery. But they are actually a result of our brains trying to predict the future. When light hits our retina, it takes about one-tenth of a second for our brain to translate that signal into perception. Evolutionary neurobiologist Mark Changizi says this neural delay makes our brains generate images of what it thinks the world will look like in one-tenth of a second. It's not always right. “Your brain is slow, so you need to basically create perceptions that correct for that delay,” said Changizi, director of human cognition at 2AI Labs. Creating an image of the very near future probably kept early humans alive because it kept them from bumping into dangerous objects or being attacked by a fast-moving predator. Click through the following images and see how our ability to predict the future one-tenth of second in advance also messes with your mind.

Ohgizmo

View Caption + #2: BLURRED LINES

When images of objects flow across the retina, it activates all these different neurons in our brains. This is the mechanism by which the brain figures out how to extrapolate the next moment. “When you move through the world, your eyes take snapshots,” said Chingazi. “During that snapshot, as something moves across your visual field, you don’t just end up with a dot on your retina, you end up with a blurred line on your retina.” Our perception doesn’t see them, but the blurred lines make our brains realize that something is in motion. From there we can determine the direction of an object moving in our world. Since the blurred lines are all emanating from a single point in your visual field, they can inform you on the direction you’re going. “Once you know the direction you’re going, you can determine how all these things would change in the next moment,” said Chingazi. Take the above photo of “warp speed.” You don’t even have to question in what direction those blurred lines are taking you. Little did you know, "Blurred Lines" is more than just the most over-hyped song of the summer.

iStockPhoto

View Caption + #3: HERING ILLUSION

Perhaps the best representation of blurred lines and how they apply to optical illusions is the Hering illusion. Its radial spokes are blurred lines, all emanating from a single point. Those lines tell us where we are heading: forwards, towards the center. The reason the two vertical lines appear to bow in the middle is because the radial lines suck our field of vision towards the center, as if we were in motion. In fact, those vertical lines are parallel, despite what our brain tells us. Our perception is actually showing us what those parallel lines look like in the next tenth of a second, the moment our gaze “passes through” the vertical lines, towards the vanishing point of the radial lines. To simplify things, Chingazi suggests we imagine walking through a very tall doorway of a cathedral. When we’re really far away, the doorway sides seem parallel to one another. The angular distance between the top, middle and bottom of the door are all roughly the same. “Once you’re really close or going through the cathedral doorway, the parts at eye-level are going to be wider apart,” he said. “When you look up, they actually converge like railroad tracks in the sky.” Essentially, this is the same phenomenon that happens in the Hering illusion.

Fibonacci

View Caption + #4: GRAND UNIFIED THEORY

Shapes aren’t the only objects that change as we move forward. Other factors like angular size -- how much of our visual field is taken up by an object – speed, distance and the color contrast between an object and its background also contribute to optical illusions. Changizi determined that many illusions can be defined within his future-seeing process, so he created a chart with 28 categories that help organize what he calls his “grand unified theory.” “This seven-by-four table really has one hypothesis that explains them all,” he said. “It makes a prediction across these 28 categories about what kind of illusions you should expect and how the illusions will reveal themselves across these 28 kinds of stimuli.” The above illusion was created by a former student of Chingizi’s, and it demonstrates elements of speed, size and contrast. Move your head towards the center and the bright-white center appears to quickly fill the circle. Move your head backward and the dark perimeter appears to close in on the white center.

David Widders

View Caption + #5: EBBINGHAUS

The orange circle on the left appears much smaller than the one on the right, when in fact they are the same size. This is the classic Ebbinghaus illusion, named after Hermann Ebbinghaus, the German psychologist who discovered it. British psychologist Edward Titchener popularized the illusion in the early 20th Century, as the illusion is also known as “Titchener circles.” The juxtaposition of the circles’ sizes and distance from each other make them appear incongruent.

Wikimedia Commons

View Caption + #6: PINK DOTS

It’s time to play magician and make the pink splotches disappear. Stare at the cross in the center of the image and before you know it, you have a completely gray rectangle. If we fixate on one single point, we tend to keep our eyes still. Those blurry pink orbs are now on the periphery of our visual field and tend to disappear because we’re zeroing in on the cross. Despite being physically present, the pink smudges do not stimulate our neurons enough to maintain visual perception. The phenomenon is known as “Troxler’s fading,” discovered by Swiss physician Ignaz Paul Vital Troxler in 1804. Although the pink dots are static, they’re actually a part of an animated illusion called the “Lilac Chaser,” created by Jeremy Hinton around 2005. In that illusion, a green dot seemingly “eats” the other dots in a clock-wise fashion, thus it’s sometimes known as the “Pac-Man” illusion.

Jeremy Hinton

View Caption + #7: CAFE WALL ILLUSION

This illusion is attributed to British psychologist Richard Gregory. Legend has it that his lab assistant saw this illusion in the wall tiles at a cafe in Bristol. The black and white pattern was offset by a half a tile, causing the illusion to appear. Though they appear to be at an angular pitch, the horizontal lines are parallel. Distance and contrast are two operating variables in this illusion. Interested in seeing the tiles at the original Bristol location? The cafe is still there, but it’s reportedly closed. However, curious trekkers can find it at the bottom of St. Michael's Hill.

Fibonacci

View Caption + #8: ROTATING SNAKES

So-called peripheral drift illusions, such as Japanese psychology professor Akiyoshi Kitaoka's “Rotating Snakes,” are motion illusions that occur in our visual periphery. These illusions work best when you look off to the side of the image. Earlier studies of the “Rotating Snakes” suggested that perceived motion was triggered by eyes moving slowly across the images. But a 2012 study, led by neuroscientist Susana Martinez-Conde, showed that fast eye movement, some of which is microscopic, drive the perceived motion.

Akiyoshi Kitaoka, Cmglee

View Caption + #9: SCINTILLATING GRID

The scintillating grid is an illusion created by superimposing white dots at the intersection of gray lines on a black background. Dark dots seem to appear and disappear at the intersections, and jump around the grid, thus the term “scintillating.” Trying to pin down one of the black dots with your gaze is like playing a hands-free version of Wack-a-Mole, as the dark spots only appear in your periphery.

Antonio Miguel de Campos

View Caption + #10: CONTRASTING RECTANGLES

One of the clearest examples of how sharp, black-and-white contrast effects the gray scale can be seen in the image above. The gray bars between the black stripes appear darker than the gray bars between the white strips. However, the gray bars are the same shade. Chingizi’s “grand unified theory” states the higher the contrasts nearby an object, the lower in contrast that object will appear.

Zhengyi

View Caption + #11: 3-D CHALK DRAWINGS

Lady, look out for that giant snail, it’s about to attack! Oh wait, shwoo, it’s only one of Julian Beever’s pavement drawings. The English artist and renowned darling of gotta-see Internet pics has been taking to streets and sidewalks all across the world since the mid 1990’s. He employs a projection technique called anamorphosis to give the illusion that his drawings are three dimensional when viewed from a certain angle.

Julian Beever

View Caption + #12: 3-D CHALK DRAWINGS, AGAIN

Shoppers in Camberley, England, got a glimpse of Santa in his snowy underground grotto courtesy of Julian Beever's amazing 3-D street art.

Idea Generation / Barcroft Media /Barcoft Media via Getty Images

View Caption + #13: SPECKLED CORKSCREW

While this image looks like a model of the future’s coolest water slide, it’s artist Anh Pham’s version of a peripheral drift illusion. Concentrate on one of the pink spots and you may be able to stop that ring from moving, but it’s a different story in your visual periphery. Good luck tearing yourself away from this one.

Anh Pham

View Caption + #14: PERSPECTIVE CHAIR

Go to any tourist destination in the world that has an iconic structure, such as the Eiffle Tour, the Taj Mahal or the Washington Monument, and you’ll find tons of fanny-packed shutter bugs creating their own optical illusions. Because objects in the distance appear smaller, altering your perception angle can make it seem like the Eiffle Tour is small enough to fit in the palm of your hand. Or that you can push against the Leaning Tower of Pisa to keep it from falling over. As the above couple demonstrates with the incredible-shrinking-man illusion, altering your perspective can drastically change your perception.

Stephanie Plick/AFP/GettyImages

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Although researchers have made remarkable advances in studying comas and other disorders of consciousness, doctors say a great deal remains unknown. When a doctor walks into an exam room, for example, the tools available for determining the prognosis of a patient in a coma are limited -- and far from an exact science.

Now, researchers think they've found a measurement that will help doctors assess whether a patient will emerge from a coma.

The Blue Brain Project is working to build a human brain -- inside a supercomputer.

NIH

“Coma is one of the most dreaded conditions,” Dr. Romer Geocadin, professor of neurology at The Johns Hopkins University School of Medicine and senior author of the new study, told Discovery News. “When patients are non-responsive from a traumatic brain injury or a stroke or tumor, for decades there’s been no real reliable marker of which patients will wake up.”

In fact, there are more reliable markers of which patients will do poorly, the researchers said.

“It’s been a one-way street,” Geocadin said.

That gave the researchers an idea: Using one of the most well-known tests for poor outcomes, they decided to test the reverse. In 1986, Dr. Allan Ropper discovered that a shift of the brain from its usual midline position is associated with loss of consciousness and poor outcome. Geocadin and lead author Robert Kowalski, a principal investigator at Craig Hospital in Englewood, Colorado, which specializes in spinal cord injury and traumatic brain injury, decided to measure whether patients whose brains shifted back toward midline had a better prognosis.

“No one had really looked at the converse; that's what we did,”  Kowalski told Discovery News.

Bryan Young, professor emeritus in the neurology department at Western University in Ontario, Canada, who was not involved in the research, called the idea to follow up on Ropper's work "simple but brilliant."

Using a year’s worth of data from new coma patients at the Neurosciences Critical Care Unit at The Johns Hopkins Hospital, the researchers not only discovered a strong association between deviation from normal brain symmetry and emerging from coma, but they were also able to pinpoint a measurement (6 millimeters) at which the association seemed to indicate improved outcome.

“The message is to (consider more than) one factor in trying to give a prognosis to a patient's family and approach to therapy,” Kowalski said. “When a patient comes in who is comatose, (clinicians can consider this and other factors in determining) what are the chances they will wake up and what should we do therapeutically?” Kowalski said.

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